Superior hydrolytic DNA cleavage by a dinuclear copper(II) N4S4-donor complex compared with a mononuclear N2S2-donor close analogue

Title: Superior hydrolytic DNA cleavage by a dinuclear copper(II) N4S4-donor complex compared with a mononuclear N2S2-donor close analogue
Creator: De, Iuliis Geoffry N.; Lawrance, Geoffrey A.; Fieuw-Makaroff, Sabine
Relation: Inorganic Chemistry Communications Vol. 3, p. 307-309
Publisher Link: http://dx.doi.org/10.1016/S1387-7003(00)00076-9
Publisher: Elsevier Science B.V.
Resource Type: journal article
Date: 2000
Description: The cleavage of plasmid DNA by a dinuclear copper(II) complex of 1,2,4,5-tetrakis(1′-amino-3′-thiabutyl)benzene is promoted significantly (rate constant of 3.3×10⁻⁵ s⁻¹ at pH 7.8 and 37℃) compared with the essentially inactive mononuclear copper(II) complex of the analogue 1,2-bis(1′-amino-3′-thiabutyl)benzene (rate constant <10⁻¹⁰ s⁻¹). This implies that the two copper ions in close proximity and acting synergetically are important in accelerating cleavage, and separate roles for the two coppers in the dimer are proposed.
Subject: DNA hydrolysis; catalysed cleavage; dicopper(II) complexes; aminothioether ligand
Identifier: uon:2960
Identifier: http://hdl.handle.net/1959.13/32229
Identifier: ISSN:1387-7003
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